שינויים מולקולאריים ומבניים באי ספיקת לב אפשרויות לטיפול עתידני
|
|
- Evan Hall
- 5 years ago
- Views:
Transcription
1 שינויים מולקולאריים ומבניים באי ספיקת לב אפשרויות לטיפול עתידני פרופ יהונתן ליאור 1
2 Braunwald s Heart Disease 8th Edition Chapter 21 Mechanisms of Cardiac Contraction and Relaxation Chapter 22 Pathophysiology of Heart failure Chapter 29 Emerging therapies 2
3 ספרות Cardiac Plasticity Joseph A. Hill, M.D., Ph.D., and Eric N. Olson, Ph.D N Eng J Med Volume 358: March 27,
4 שאלה מדידה שלו בדם 6 שעות מהסמנים ומנבאת פרוגנוזה לאחר אוטם שריר הלב )ברנוולד פרק ( טרופונין T טרופונין I נטריורטיק פפטיד קולגן
5 שאלה יעכב הכל למעט )סמן תשובה לא ACE מתן מעכבי ( נכונה Beta-adrenergic desensitization Fetal gene expression Myocyte necrosis MMP activation E-C coupling
6 Main Topics 1. LV remodeling -cellular and molecular level 2. Extracellular matrix 3. Regeneration 6
7 Myocardium 1. Cardiomyocytes and nonmyocyte cells 2. Extracellular Matrix 3. Vessels 7
8 Myocardial Cells Jugdutt & al. Circulation
9 The Sarcomere Figure 19-1 Braunwald
10 10
11 Cardiac Damage and Repair 11
12 Apoptosis vs. Necrosis 12
13 Myocyte Cell Death Necrosis Apoptosis Autophagy 13
14 Healing Nomenclature Regeneration Repair Damaged tissue is Damaged tissue is replaced from replaced by parenchyma. fibrous scar tissue. 14
15 Ventricular remodeling, comprising changes in mass, volume, shape, and composition, constitutes one of the principal mechanisms by which the heart compensates for an increased load 15
16 16
17 LV Dilatation 17
18 Cardiac Support Device Figure
19 19
20
21 Cellular Events Triggered by Altered Workload. A complex interplay of biomechanical and neurohumoral stress responses culminates in hypertrophic gene regulation and cell growth Hill & Olson NEJM 2008
22 Pathogenesis of heart failure
23 23
24 Overview of the pathophysiology of myocardial remodeling Figure
25 Cellular Hypertrophy 25
26 Cardiac myocyte remodeling Increased myocyte length and width 26
27 cardiac hypertrophy Figure
28 Autophagy 28
29 Small RNAs in a big heart
30 Figure 69-6 The flow of genetic information. Transcription in the nucleus creates a complementary ribonucleic acid copy from one of the DNA strands in the double helix. mrna is transported into the cytoplasm, where it is translated into protein
31 MicroRNAs as Mediators MicroRNAs as Mediators Mann D. N Engl J Med 2007;356:
32 Human mutations affecting Ca2+ cycling proteins J. Clin. Invest. 115: (2005) Braunwald p
33 Calcium Hemostasis in Failing Human Myocardium Intracellular Calcium levels Basal (diastolic) Peak (systolic) Rate of fall with diastole From Braunwald pp 33
34 Alterations in beta-adrenergic pathways in the failing heart 34
35
36 Braunwald Table
37 Braunwald Table 29-6 Effect of Gene Polymorphisms on the Pharmacological Treatment of Heart Failure 37
38 38
39 Extra Cellular Matrix 39
40 MMP activity site Extra cellular matrix degradation causes cardiomyocyte realignment wall thinning LV dilatation heart failure 40
41 The regulation of extracellular matrix degradation Figure
42 Factors responsible for diastolic dysfunction Figure
43 FIGURE 22-4 The systemic and tissue components of the renin-angiotensin system 43
44 Angiotensin II and Myocardium Myocyte hypertrophy Myocyte apoptosis Fibrosis Matrix remodeling (collagen deposition) Inflammation Oxidative stress 44
45 Summary LV Remodeling at the molecular and cellular level 1. Myocyte growth or hypertrophy. 2. Changes in myocyte phenotype with reexpression of fetal gene programs. 3. Alterations in proteins involved in excitationcontraction coupling and contraction. 4. Myocyte death due to necrosis and apoptosis 5. Changes in the extracellular matrix. 6. Abnormalities in energetics. 45
46 Processes Occurring in Ventricular Remodeling (2) Continued expansion of infarct zone Dilation and reshaping of the left ventricle Myocyte hypertrophy Ongoing myocyte loss Excessive accumulation of collagen in the cardiac interstitium 46
47 Table 22-5
48 Myocardial regeneration and repair 48
49 Stem Cell Self renewal Give rise to specialized cells. 49
50 Embryonic and Adult Stem Cells Zipori
51 Cardiac Stem cells 51
52 Myocardial repair Figure
53 Induced Pluripotent Stem cells ips 53
54 Possible mechanisms for successful cardiac regenerative therapy Boyle et al Circulation 2006 Prof. Jonathan Leor, NCRI 54
55 FIGURE 29-3 Proposed mechanisms of action of stem/progenitor cells in cardiovascular repair. 55
56 Future directions Braunwald future therapies will likely be focused on reversing and/or stabilizing the downstream biological consequences of neurohormonal activation, rather than on neurohormonal activation per se. 56
57 Sleeping Student: Take home message 57
58 Overview of the pathophysiology of myocardial remodeling Figure
1. Cardiomyocytes and nonmyocyte. 2. Extracellular Matrix 3. Vessels שאלה 1. Pathobiology of Heart Failure Molecular and Cellular Mechanism
Pathobiology of Heart Failure Molecular and Cellular Mechanism Jonathan Leor Neufeld Cardiac Research Institute Tel-Aviv University Sheba Medical Center, Tel-Hashomer שאלה 1 התא הנפוץ ביותר (75%~) בלב
More informationIn Vivo Animal Models of Heart Disease. Why Animal Models of Disease? Timothy A Hacker, PhD Department of Medicine University of Wisconsin-Madison
In Vivo Animal Models of Heart Disease Timothy A Hacker, PhD Department of Medicine University of Wisconsin-Madison Why Animal Models of Disease? Heart Failure (HF) Leading cause of morbidity and mortality
More informationDOWNLOAD PDF CARDIAC REMODELING AND CELL DEATH IN HEART FAILURE
Chapter 1 : The fibrosis-cell death axis in heart failure Remodeling may be defined as changes in the morphology, structure, and function of the heart related to alterations in loading conditions and/or
More informationRisk Stratification in Heart Failure: The Role of Emerging Biomarkers
Risk Stratification in Heart Failure: The Role of Emerging Biomarkers David G. Grenache, PhD Associate Professor of Pathology, University of Utah Medical Director, ARUP Laboratories Salt Lake City, UT
More informationIndex. A Action potential duration, increased, by decreases in sodium current,
Heart Failure Clin 1 (2005) 313 319 Index Note: Page numbers of article titles are in boldface type. A Action potential duration, increased, by decreases in sodium current, 201 202 Adenylyl cyclase, overexpression
More informationTissue repair. (3&4 of 4)
Tissue repair (3&4 of 4) What will we discuss today: Regeneration in tissue repair Scar formation Cutaneous wound healing Pathologic aspects of repair Regeneration in tissue repair Labile tissues rapid
More informationDIASTOLIC HEART FAILURE
DIASTOLIC HEART FAILURE M Mohsen Ibrahim, MD Alexandria, Proposed Criteria for Diastolic Heart Failure ESC Working Group (EHJ 1998) CHF signs/symptoms EF 45% Hemodynamic or echo evidence of diastolic dysfunction
More informationEarly Career Investigator Awards. 84 Lipid and Lipoprotein Metabolism: Clinical Lifestyle & Behavioral Medicine
AHA Scientific Sessions Awards and Travel Grants Available by Abstract Category and Award applicants must have submitted an abstract to a category listed under that award and be a member of award s the
More informationChapter Skeletal Muscle Structure and Function
Chapter 10.2 Skeletal Muscle Structure and Function Introduction to Muscle Physiology Movement is a fundamental characteristic of all living things All muscle cells (skeletal, cardiac, and smooth) are
More informationRemodeling the failing heart: : the biology and future treatment options
Remodeling the failing heart: : the biology and future treatment options J-L Balligand (UCL-Brussels, BE) jl.balligand@uclouvain.be Myocardial remodeling: definitions phenotypic plasticity : remodeling
More informationAge-related changes in cardiovascular system. Dr. Rehab Gwada
Age-related changes in cardiovascular system Dr. Rehab Gwada Objectives explain the main structural and functional changes in cardiovascular system associated with normal aging Introduction aging results
More informationBiomarkers in cardiovascular disease. Felix J. Rogers, DO, FACOI April 29, 2018
Biomarkers in cardiovascular disease Felix J. Rogers, DO, FACOI April 29, 2018 Biomarkers NIH: A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological
More informationMedical management of LV aneurysm and subsequent cardiac remodeling: is it enough? J. Parissis Attikon University Hospital Athens, Greece
Medical management of LV aneurysm and subsequent cardiac remodeling: is it enough? J. Parissis Attikon University Hospital Athens, Greece Disclosures Grants: ALARM investigator received research grants
More informationCKD Satellite Symposium
CKD Satellite Symposium Recommended Therapy by Heart Failure Stage AHA/ACC Task Force on Practice Guideline 2001 Natural History of Heart Failure Patients surviving % Mechanism of death Sudden death 40%
More informationSUPPLEMENTARY INFORMATION
doi:10.1038/nature10188 Supplementary Figure 1. Embryonic epicardial genes are down-regulated from midgestation stages and barely detectable post-natally. Real time qrt-pcr revealed a significant down-regulation
More informationMyocardial Infarction
Myocardial Infarction MI = heart attack Defined as necrosis of heart muscle resulting from ischemia. A very significant cause of death worldwide. of these deaths, 33% -50% die before they can reach the
More informationLeft ventricular hypertrophy: why does it happen?
Nephrol Dial Transplant (2003) 18 [Suppl 8]: viii2 viii6 DOI: 10.1093/ndt/gfg1083 Left ventricular hypertrophy: why does it happen? Gerard M. London Department of Nephrology and Dialysis, Manhes Hospital,
More informationExtracellular matrix Basic and translational science: Highlights of the congress
Extracellular matrix Basic and translational science: Highlights of the congress Stephane Heymans, Maastricht University Medical Centre, CARIM, Netherlands Speaker The extracellular matrix modulates cardiac
More informationPathophysiology of Coronary Microvascular Dysfunction
Pathophysiology of Coronary Microvascular Dysfunction Cheol Woong Yu, MD, PhD Cardiology Department Division of Internal Medicine Korea University Anam Hospital. Etiologies of Chest Pain without obstructive
More informationInternational Graduate Research Programme in Cardiovascular Science
1 International Graduate Research Programme in Cardiovascular Science This work has been supported by the European Community s Sixth Framework Programme under grant agreement n LSHM-CT-2005-01883 EUGeneHeart.
More informationHeart Failure (HF) Treatment
Heart Failure (HF) Treatment Heart Failure (HF) Complex, progressive disorder. The heart is unable to pump sufficient blood to meet the needs of the body. Its cardinal symptoms are dyspnea, fatigue, and
More informationLong-Term Management: Preventing Progression. Daniel Burkhoff Cardiovascular Research Foundation and Columbia University
Long-Term Management: Preventing Progression Daniel Burkhoff Cardiovascular Research Foundation and Columbia University Disclosure Unrestricted institutional (CRF) educational grant from Abiomed Left Ventricular
More informationTEACH Lesson Plan Manual for Herlihy s The Human Body in Health and Illness 5 th edition
TEACH Lesson Plan Manual for Herlihy s The Human Body in Health and Illness 5 th edition Chapter 17 Function of the Heart Lesson 17.1 Function of the Heart 1. Define cardiac cycle with respect to systole
More informationAtlas of HEART FAILURE. Cardiac Function and Dysfunction Fourth Edition
Atlas of HEART FAILURE Cardiac Function and Dysfunction Fourth Edition Atlas of HEART FAILURE Cardiac Function and Dysfunction Fourth Edition Editor Wilson S. Colucci, MD Professor of Medicine Boston University
More informationHYPERTENSION AND HEART FAILURE
HYPERTENSION AND HEART FAILURE Kenya Cardiac Society Symposium Feb 2017 Dr Jeilan Mohamed No conflict of interests . Geoffrey, 45 yr old hypertensive office worker male from Nairobi, has just watched his
More informationSPECIAL PATHOPHYSIOLOGY CARDIO-VASCULAR SYSTEM
1. Myocardia lischemia is mainly a result of: 1.Coronary hypoxemia. 2. Coronary artery disease (CAD). 3. Acute coronaritis. 4. Coronary anemia. 5. Heart remodelling. SPECIAL PATHOPHYSIOLOGY CARDIO-VASCULAR
More informationBiomarkers for Personalized Medicine and Regenerative Therapy
Biomarkers for Personalized Medicine and Regenerative Therapy Bettina Heidecker, MD University of Miami Division of Cardiology Interdisciplinary Stem Cell Institute Biomarkers in Heart Failure Growing
More informationJournal Club Semmler Lorenz
Beer et al. 2015 - Analysis of the Secretome of Apoptotic Peripheral Blood Mononuclear Cells: Impact of Released Proteins and Exosomes for Tissue Regeneration Journal Club 13.11.2017 1 Introduction to
More informationDeclaration of conflict of interest. I have nothing to disclose.
Declaration of conflict of interest I have nothing to disclose. Left Bundle branch block in HF: DO GENETICS MATTER? Silvia Giuliana Priori Cardiovascular Genetics, Langone Medical Center, New York University
More informationIschemic heart disease
Ischemic heart disease Introduction In > 90% of cases: the cause is: reduced coronary blood flow secondary to: obstructive atherosclerotic vascular disease so most of the time it is called: coronary artery
More informationCells & Tissues. Chapter 3
Cells & Tissues Chapter 3 Cell Theory Cell is structural and functional unit of life Activity of an organism is dependent upon its cells Principle of Complementarity functions of cells are dependent upon
More informationENDOGENOUS CARDIAC STEM CELLS IN THE REGENERATION OF ACUTE AND CHRONIC ISCHEMIC MYOCARDIUM
ENDOGENOUS CARDIAC STEM CELLS IN THE REGENERATION OF ACUTE AND CHRONIC ISCHEMIC MYOCARDIUM Bernardo Nadal-Ginard, M.D., Ph.D. New York Medical College Angioplasty Summit 2004, Seoul 04/29/04 MYOCARDIAL
More informationOutline. Pathophysiology: Heart Failure. Heart Failure. Heart Failure: Definitions. Etiologies. Etiologies
Outline Pathophysiology: Mat Maurer, MD Irving Assistant Professor of Medicine Definitions and Classifications Epidemiology Muscle and Chamber Function Pathophysiology : Definitions An inability of the
More informationSmall Platform Catheter-Based Left Ventricular Assist Device Support Suppresses Cardioprotective Beta Arrestin- Mediated Signal Transduction
Small Platform Catheter-Based Left Ventricular Assist Device Support Suppresses Cardioprotective Beta Arrestin- Mediated Signal Transduction Keshava Rajagopal, MD PhD, Progyaparamita Saha, PhD, Isa Mohammed,
More informationPathology of Hypertension
2016-03-07 Pathology of Hypertension Honghe Zhang honghezhang@zju.edu.cn Tel:88208199 Department of Pathology ❶ Genetic predisposition ❷ Dietary factors ❸ Environmental factors ❹ Others Definition and
More informationImages have been removed from the PowerPoint slides in this handout due to copyright restrictions.
Heart Failure Heart Failure Introduction and History AHA 2015 Statistics About 6 million Americans 870,000 new cases each year 1 in 9 deaths related to HF Almost 1 million hospitalizations each year (cost
More informationParacrine Mechanisms in Adult Stem Cell Signaling and Therapy
Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy Massimiliano Gnecchi, Zhiping Zhang, Aiguo Ni, Victor J. Dzau Circulation Research 2008 Nov 21;103(11):1204-19 Introduction(1) After AMI all
More informationCardiomyopathy. ACOI IM Board Review 2018 Martin C. Burke DO, FACOI
Cardiomyopathy ACOI IM Board Review 2018 Martin C. Burke DO, FACOI No Disclosures Cardiomyopathies Definition: diseases of heart muscle 1980 WHO: unknown causes Not clinically relevant 1995 WHO: diseases
More informationThe Cardiovascular System and Aging- Is it Built to Fail?
The Cardiovascular System and Aging- Is it Built to Fail? Francis G. Spinale, MD, PhD Professor of Surgery and Cell Biology and Anatomy University of South Carolina School of Medicine Veterans Affairs
More information1) Severe, crushing substernal chest pain 2) radiate to the neck, jaw, epigastrium, or left arm. 3- rapid and weak pulse 4- nausea (posterior MI).
1) Severe, crushing substernal chest pain 2) radiate to the neck, jaw, epigastrium, or left arm. 3- rapid and weak pulse 4- nausea (posterior MI). 5- cardiogenic shock (massive MIs >40% of the left ventricle)
More informationLecture Overview. CT Framework of the Body. Chapter 4 Muscle & Nervous Tissues Lecture 11. Connective tissue framework of the body
Visual Anatomy & Physiology First Edition Martini & Ober Chapter 4 Muscle & Nervous Tissues Lecture 11 Lecture Overview Connective tissue framework of the body Introduction to muscle tissue Classification/characteristics
More informationCT for Myocardial Characterization of Cardiomyopathy. Byoung Wook Choi, Yonsei University Severance Hospital, Seoul, Korea
CT for Myocardial Characterization of Cardiomyopathy Byoung Wook Choi, Yonsei University Severance Hospital, Seoul, Korea Cardiomyopathy Elliott P et al. Eur Heart J 2008;29:270-276 The European Society
More informationCardiac Care in pa+ents with Duchenne muscular dystrophy
Cardiac Care in pa+ents with Duchenne muscular dystrophy Linda Cripe, M.D. Professor of Pediatrics The Heart Center.... Why are cardiologists interested in patients with Duchenne muscular dystrophy?....
More informationCARDIAC HYPERTROPHY: PATHOPHYSIOLOGY AND PROGRESSION TO FAILURE
Heart Failure The abnormalities described above often culminate in heart failure, an extremely common result of many forms of heart disease. In heart failure, often called congestive heart failure (CHF),
More informationChallenging Issues in Cardiac Biomarker interpretation. F. Nikaeen. MD interventional Cardiologist
Challenging Issues in Cardiac Biomarker interpretation F. Nikaeen. MD interventional Cardiologist Biomarkers Types of Troponin Troponin C Binds calcium Troponin I Binds actin Troponin T Binds tropomyosin
More informationTissue renewal and Repair. Nisamanee Charoenchon, PhD Department of Pathobiology, Faculty of Science
Tissue renewal and Repair Nisamanee Charoenchon, PhD Email: nisamanee.cha@mahidol.ac.th Department of Pathobiology, Faculty of Science Topic Objectives 1. Describe processes of tissue repair, regeneration
More informationDespite repeated attempts to develop a unifying hypothesis
Basic Science for Clinicians Mechanisms and Models in Heart Failure The Biomechanical Model and Beyond Douglas L. Mann, MD; Michael R. Bristow, MD, PhD Despite repeated attempts to develop a unifying hypothesis
More informationDefinition of Congestive Heart Failure
Heart Failure Definition of Congestive Heart Failure A clinical syndrome of signs & symptoms resulting from the heart s inability to supply adequate tissue perfusion. CHF Epidemiology Affects 4.7 million
More informationDiastolic Heart Failure. Edwin Tulloch-Reid MBBS FACC Consultant Cardiologist Heart Institute of the Caribbean December 2012
Diastolic Heart Failure Edwin Tulloch-Reid MBBS FACC Consultant Cardiologist Heart Institute of the Caribbean December 2012 Disclosures Have spoken for Merck, Sharpe and Dohme Sat on a physician advisory
More informationPressure-calcium relationships in perfused mouse hearts
Pressure-calcium relationships in perfused mouse hearts Guy A. MacGowan, Jonathan A. Kirk, Caroline Evans and Sanjeev G. Shroff AJP - Heart 290:2614-2624, 2006. First published Jan 13, 2006; doi:10.1152/ajpheart.00979.2005
More informationConsequences of Cardiomyopathy. thickened and stiff, the left ventricle is most often affected. This results in a lack of pumping
Roseanne Baird March 30, 2010 BI 104 Dr. Hammoudi Consequences of Cardiomyopathy Cardiomyopathy is a disease in which the myocardium of the heart becomes enlarged, thickened and stiff, the left ventricle
More informationPROTEIN SYNTHESIS. It is known today that GENES direct the production of the proteins that determine the phonotypical characteristics of organisms.
PROTEIN SYNTHESIS It is known today that GENES direct the production of the proteins that determine the phonotypical characteristics of organisms.» GENES = a sequence of nucleotides in DNA that performs
More informationDiastolic Function. Rick Nishimura Leighton Professor of CV Diseases Mayo Clinic No Disclosures
Diastolic Function Rick Nishimura Leighton Professor of CV Diseases Mayo Clinic No Disclosures Heart = Pump Heart Failure Systolic Dysfunction Diastolic Dysfunction Diastole is a complex sequence of multiple
More informationUncovering the mechanisms of wound healing and fibrosis
Any Questions??? Ask now or contact support support@sabiosciences.com 1-888-503-3187 International customers: SABio@Qiagen.com Uncovering the mechanisms of wound healing and fibrosis Webinar related questions:
More informationDiastolic Dysfunction: Hypertension to Hypertrophy to Heart Failure
Diastolic Dysfunction: Hypertension to Hypertrophy to Heart Failure Dr. Shelley Zieroth FRCPC Assistant Professor, Cardiology, University of Manitoba Director of Cardiac Transplant and Heart Failure Clinics
More informationDISEASE ETIOLOGY. Dynamic condition Morpho-functional alteration of one or more organ/tissue Acute or chronic Localized or systemic
DISEASE Dynamic condition Morpho-functional alteration of one or more organ/tissue Acute or chronic Localized or systemic Etiology = studies the causes of disease Pathogenesis = starting from etiology,
More informationChapter 10. Learning Objectives. Learning Objectives 9/11/2012. Congestive Heart Failure
Chapter 10 Congestive Heart Failure Learning Objectives Explain concept of polypharmacy in treatment of congestive heart failure Explain function of diuretics Learning Objectives Discuss drugs used for
More informationPathophysiology: Heart Failure
Pathophysiology: Heart Failure Mat Maurer, MD Irving Assistant Professor of Medicine Outline Definitions and Classifications Epidemiology Muscle and Chamber Function Pathophysiology Heart Failure: Definitions
More informationCell implantation after myocardial infarction: a 10 years experience from the ICREC laboratory
Cell implantation after myocardial infarction: a 10 years experience from the ICREC laboratory BANFF-SCT Joint Scientific Meeting 2017 Barcelona, 29 th March Santi Roura, PhD Grup ICREC IGTP HuGTiP (Badalona)
More informationReview of Cardiac Imaging Modalities in the Renal Patient. George Youssef
Review of Cardiac Imaging Modalities in the Renal Patient George Youssef ECHO Left ventricular hypertrophy (LVH) assessment Diastolic dysfunction Stress ECHO Cardiac CT angiography Echocardiography - positives
More informationFOCUS ON CARDIOVASCULAR DISEASE
The Consequences of Vitamin D Deficiency: FOCUS ON CARDIOVASCULAR DISEASE Vitamin D deficiency is a global health problem. With all the medical advances of the century, vitamin D deficiency is still epidemic.
More informationMyocardial infarction
NEW CARDIAC MARKERS AND CARDIAC REGENERATION Päivi Lakkisto, MD, PhD Specialist in Clinical Chemistry Clinical lecturer University of Helsinki and HUSLAB Minerva Institute for Medical Research Myocardial
More informationHeart Failure with Preserved Ejection Fraction: Mechanisms and Management
Heart Failure with Preserved Ejection Fraction: Mechanisms and Management Jay N. Cohn, M.D. Professor of Medicine Director, Rasmussen Center for Cardiovascular Disease Prevention University of Minnesota
More informationBlood Vessels. Dr. Nabila Hamdi MD, PhD
Blood Vessels Dr. Nabila Hamdi MD, PhD ILOs Understand the structure and function of blood vessels. Discuss the different mechanisms of blood pressure regulation. Compare and contrast the following types
More informationDiastolic Heart Failure
Diastolic Heart Failure Presented by: Robert Roberts, M.D., FRCPC, MACC, FAHA, FRSC Professor of Medicine and Chair ISCTR University of Arizona, College of Medicine Phoenix Scientist Emeritus and Advisor,
More informationPhysiology sheet #2. The heart composed of 3 layers that line its lumen and cover it from out side, these layers are :
Physiology sheet #2 * We will talk in this lecture about cardiac muscle physiology, the mechanism and the energy sources of their contraction and intracellular calcium homeostasis. # Slide 4 : The heart
More informationThe biological bases of treatment related cardiac and lung toxicity
The biological bases of treatment related cardiac and lung toxicity Monica Mangoni Cardiopulmonary toxicity of anticancer treatments Chemotherapy TKIs MoAB CARDIAC TOXICITY Radiation effect -------------------------------Early
More informationrenoprotection therapy goals 208, 209
Subject Index Aldosterone, plasminogen activator inhibitor-1 induction 163, 164, 168 Aminopeptidases angiotensin II processing 64 66, 214 diabetic expression 214, 215 Angiotensin I intrarenal compartmentalization
More informationPercutaneous ventricular partitioning
Emerging interventional technologies for heart failure management Percutaneous ventricular partitioning Hüseyin Ince MD, PhD University of Rostock Germany Potential conflicts of interest Speaker s name:
More informationCardiac Drugs: Chapter 9 Worksheet Cardiac Agents. 1. drugs affect the rate of the heart and can either increase its rate or decrease its rate.
Complete the following. 1. drugs affect the rate of the heart and can either increase its rate or decrease its rate. 2. drugs affect the force of contraction and can be either positive or negative. 3.
More informationAlfonso López. Cardiac Hypertrophy and Dilation
Cardiac Hypertrophy and Dilation Alfonso López Professor of Anatomic Pathology Dept. Pathology and Microbiology Atlantic Veterinary College University of Prince Edward Island Canada Jan 23, 2012 Compensatory
More informationCardiac MRI: Clinical Application to Disease
Cardiac MRI: Clinical Application to Disease Jessi Smith, MD Cardiothoracic imaging, Indiana University Slides courtesy of Stacy Rissing, MD Outline Imaging planes Disease findings Pulse sequences used
More informationCirculation. Blood Pressure and Antihypertensive Medications. Venous Return. Arterial flow. Regulation of Cardiac Output.
Circulation Blood Pressure and Antihypertensive Medications Two systems Pulmonary (low pressure) Systemic (high pressure) Aorta 120 mmhg Large arteries 110 mmhg Arterioles 40 mmhg Arteriolar capillaries
More informationStratification of heart failure using biomarkers of myocardial fibrosis
Stratification of heart failure using biomarkers of myocardial fibrosis Thesis Master Biology of Disease University of Utrecht Sanne de Jong 0476773 Supervisor: Dr. H.V.M. van Rijen University Medical
More informationIn the name of GOD. Animal models of cardiovascular diseases: myocardial infarction & hypertension
In the name of GOD Animal models of cardiovascular diseases: myocardial infarction & hypertension 44 Presentation outline: Cardiovascular diseases Acute myocardial infarction Animal models for myocardial
More informationCardiovascular System. Heart
Cardiovascular System Heart Electrocardiogram A device that records the electrical activity of the heart. Measuring the relative electrical activity of one heart cycle. A complete contraction and relaxation.
More informationThyroid hormone and cardiac regeneration: from Prometheus myth to reality
Thyroid hormone and cardiac regeneration: from Prometheus myth to reality C. Pantos Unit of Cardiac Regeneration and Cardiopreservation - University of Athens Regeneration : an old concept Amphibian metamorphosis
More informationCardiac MRI: Clinical Application to Disease
Cardiac MRI: Clinical Application to Disease Stacy Rissing, MD! Cardiothoracic imaging, Indiana University! Outline Imaging planes Disease findings Pulse sequences used for each indication Pathophysiology
More informationCordis EXOSEAL Vascular Closure Device
to receive our latest news and key activities. Cordis EXOSEAL Vascular Closure Device Polyglycolic Acid Plug (PGA) Material Absorption and Tissue Reaction Assessment 3 Days* 14 Days* 60 Days* LinkedIn
More informationDr. Alexander Lyon Senior Lecturer and Consultant Cardiologist Clinical Lead in Cardio-Oncology Royal Brompton Hospital, London UK
Advanced heart failure - devices, mechanical circulatory support and cardiac transplantation Monday 30 January 2017 Stem cell and gene therapies for heart failure Dr. Alexander Lyon Senior Lecturer and
More informationSections 12.3, 13.1, 13.2
Sections 12.3, 13.1, 13.2 Now that the DNA has been copied, it needs to send its genetic message to the ribosomes so proteins can be made Transcription: synthesis (making of) an RNA molecule from a DNA
More informationProkaryotes and eukaryotes alter gene expression in response to their changing environment
Chapter 18 Prokaryotes and eukaryotes alter gene expression in response to their changing environment In multicellular eukaryotes, gene expression regulates development and is responsible for differences
More informationMicroRNA in Cancer Karen Dybkær 2013
MicroRNA in Cancer Karen Dybkær RNA Ribonucleic acid Types -Coding: messenger RNA (mrna) coding for proteins -Non-coding regulating protein formation Ribosomal RNA (rrna) Transfer RNA (trna) Small nuclear
More informationΗ επίδραση της ηλικίας στη δομή και λειτουργία του μυοκαρδίου στους ηλικιωμένους
Η επίδραση της ηλικίας στη δομή και λειτουργία του μυοκαρδίου στους ηλικιωμένους Ελένη Νάκου Καρδιολογική Κλινική, Πανεπιστημιακό Νοσοκομείο Ηρακλείου None Disclosures Time modifies many biologic processes
More informationX/04/$20.00/0 Endocrine Reviews 25(4): Copyright 2004 by The Endocrine Society doi: /er
0163-769X/04/$20.00/0 Endocrine Reviews 25(4):543 567 Printed in U.S.A. Copyright 2004 by The Endocrine Society doi: 10.1210/er.2003-0012 Diabetic Cardiomyopathy: Evidence, Mechanisms, and Therapeutic
More informationCARDIOVASCULAR SYSTEM
CARDIOVASCULAR SYSTEM Overview Heart and Vessels 2 Major Divisions Pulmonary Circuit Systemic Circuit Closed and Continuous Loop Location Aorta Superior vena cava Right lung Pulmonary trunk Base of heart
More informationUnderstanding and Development of New Therapies for Heart Failure - Lessons from Recent Clinical Trials -
Understanding and Development of New Therapies for Heart Failure - Lessons from Recent Clinical Trials - Clinical trials Evidence-based medicine, clinical practice Impact upon Understanding pathophysiology
More informationRV dysfunction and failure PATHOPHYSIOLOGY. Adam Torbicki MD, Dept Chest Medicine Institute of Tuberculosis and Lung Diseases Warszawa, Poland
RV dysfunction and failure PATHOPHYSIOLOGY Adam Torbicki MD, Dept Chest Medicine Institute of Tuberculosis and Lung Diseases Warszawa, Poland Normal Right Ventricle (RV) Thinner wall Weaker myocytes Differences
More informationJ Jpn Coll Angiol, 2009, 49:
Online publication October 6, 2009 48 2 20 J Jpn Coll Angiol, 2009, 49: 293 297 atrial natriuretic peptide, brain natriuretic peptide, guanylyl cyclase-a receptor, cardiac remodeling, cardiac hypertrophy
More informationMolecular Basis of Sex Differences in Cardiac Hypertrophy and Heart Failure
Eastern Kentucky University Encompass Online Theses and Dissertations Student Scholarship January 2016 Molecular Basis of Sex Differences in Cardiac Hypertrophy and Heart Failure Maya James Eastern Kentucky
More informationPathophysiology: Heart Failure. Objectives
Pathophysiology: Heart Failure Mat Maurer, MD Irving Assistant Professor of Clinical Medicine Objectives At the conclusion of this seminar, learner will be able to: 1. Define heart failure as a clinical
More informationRecovery of Myocardial Infarction via Unique Modulation of the Cardiac Microenvironment
2016 춘계심혈관통합학술대회, 경주 Recovery of Myocardial Infarction via Unique Modulation of the Cardiac Microenvironment Youngkeun Ahn, MD, PhD Department of Cardiology, Cardiovascular Center Chonnam National University
More informationMuscle tissues. Dr. Hersh Abdul Ham-Karim BVM&S, PG Dip, MSc and PhD
Muscle tissues Dr. Hersh Abdul Ham-Karim BVM&S, PG Dip, MSc and PhD Muscle tissue is a soft tissue that composes muscles in animal bodies, and gives rise to muscles' ability to contract. Muscle tissue
More informationDetection and Assessment of MI: Use of Imaging Methods. Robert O. Bonow, M.D.
Detection and Assessment of MI: Use of Imaging Methods Robert O. Bonow, M.D. Detection and Assessment of MI: Use of Imaging Methods Robert O. Bonow, M.D. No Relationships to Disclose Expert Consensus Document
More informationMesenchymal Stem Cells to Repair Vascular Damage after Chemotherapy: Past, Present and Future
Mesenchymal Stem Cells to Repair Vascular Damage after Chemotherapy: Past, Present and Future Cell Therapy 2014 Las Vegas, NV, USA Sulaiman Al-Hashmi, PhD Sultan Qaboos University Oman What are MSCs? Stem
More informationLeft heart failure and right heart failure because of pulmonary disease
Left heart failure and right heart failure because of pulmonary disease Dr. Szathmári Miklós Semmelweis University First Department of Medicine 28. Oct. 2013. Heart failure (HF)- definition HF is a clinical
More informationMuscle Cells & Muscle Fiber Contractions. Packet #8
Muscle Cells & Muscle Fiber Contractions Packet #8 Skeletal muscle is attached to bones and is responsible for movement. Introduction Introduction II Skeletal muscle is composed of bundles of muscle fibers
More informationTreatment of Heart Failure: Current Recommendation Waiz A
Treatment of Heart Failure: Current Recommendation Waiz A The impaired left ventricular emptying that characterizes heart failure may result from a variety of cardiac diseases, including myocardial ischaemia
More informationConnective tissue MUSCLE TISSUE
Connective tissue MUSCLE TISSUE Part 1 General features of MT Develop from mesoderm Many cells, less intercellular matrix Function contraction (shortening) Skeletal (striated, voluntary) Types of MT Cardiac
More information